Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Dec 6, 2025

A Behavioral Assay to Measure Responsiveness of Zebrafish to Changes in Light Intensities
09:39

A Behavioral Assay to Measure Responsiveness of Zebrafish to Changes in Light Intensities

Published on: October 3, 2008

16.9K

Rods Contribute to Visual Behavior in Larval Zebrafish.

Prahatha Venkatraman1, Ishara Mills-Henry2, Karthik Ramaswamy Padmanabhan1

  • 1Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States.

Investigative Ophthalmology & Visual Science
|October 13, 2020
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correlations between Clinical Activity Score and Serological and Radiological Data in Treatment-naïve Ethnic Han Chinese Thyroid Eye Disease.

Ophthalmic research·2026
Same author

Association between secondhand smoke exposure and ocular microbiome changes in children.

Current research in microbial sciences·2026
Same author

Associations of Multiomics Biological Aging With Diabetic Retinopathy and Life Expectancy.

Investigative ophthalmology & visual science·2026
Same author

An AI-Based OCT System to Detect Diabetic Macular Edema: A Prospective Validation and Noninferiority Randomized Clinical Trial.

JAMA·2026
Same author

Thyroid eye disease in paediatric Graves' disease: a case series from the Gulf region with comparison to adults.

International ophthalmology·2026
Same author

Profiling of ocular surface microbiome and its ocular types in children and adolescents.

Communications medicine·2026
Same journal

Degeneration of Interpericyte Tunneling Nanotubes Can Occur in the Absence of Pericyte Loss in Diabetic Retina Disease.

Investigative ophthalmology & visual science·2026
Same journal

Unsupervised Clustering for POAG Phenotyping.

Investigative ophthalmology & visual science·2026
Same journal

Myd88 Deficiency Accelerates Retinal Degeneration and Alters Microglial Dynamics in a Mouse Model of Retinitis Pigmentosa.

Investigative ophthalmology & visual science·2026
Same journal

Sigma 1 Receptor Activation Coordinates Metabolic Stress Responses to Protect Retinal Vasculature in Ischemic Retinopathy.

Investigative ophthalmology & visual science·2026
Same journal

On the Misuse of Virus-Transformed Human Corneal Epithelial Cells as Surrogates for Normal Cells.

Investigative ophthalmology & visual science·2026
Same journal

Human Crystallin Variation and Cataract.

Investigative ophthalmology & visual science·2026
See all related articles
This summary is machine-generated.

Young zebrafish rods are functional and contribute to visual behaviors as early as 6 days postfertilization (dpf). This study confirmed rod function in larval zebrafish using electroretinograms (ERGs) and behavioral assays.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Vision Science

Background:

  • Zebrafish rod photoreceptors develop early but are considered mature and functional later, around 15-21 days postfertilization (dpf).
  • Previous research suggested potential early rod functionality, detecting electroretinograms (ERGs) in young rods at 5 dpf.

Purpose of the Study:

  • To investigate whether early-developing rods in zebrafish larvae are functional.
  • To determine if these young rods can mediate behavioral responses.

Main Methods:

  • Confirmed rod function in no optokinetic response f (nof) mutants at 6 dpf using ERGs under photopic and scotopic conditions.
  • Assessed the role of rods in visual behaviors (visual-motor response and optokinetic response) in wild-type and nof mutant larvae.

More Related Videos

The Optokinetic Response as a Quantitative Measure of Visual Acuity in Zebrafish
04:56

The Optokinetic Response as a Quantitative Measure of Visual Acuity in Zebrafish

Published on: October 9, 2013

20.9K
Electroretinogram Analysis of the Visual Response in Zebrafish Larvae
09:44

Electroretinogram Analysis of the Visual Response in Zebrafish Larvae

Published on: March 16, 2015

16.0K

Related Experiment Videos

Last Updated: Dec 6, 2025

A Behavioral Assay to Measure Responsiveness of Zebrafish to Changes in Light Intensities
09:39

A Behavioral Assay to Measure Responsiveness of Zebrafish to Changes in Light Intensities

Published on: October 3, 2008

16.9K
The Optokinetic Response as a Quantitative Measure of Visual Acuity in Zebrafish
04:56

The Optokinetic Response as a Quantitative Measure of Visual Acuity in Zebrafish

Published on: October 9, 2013

20.9K
Electroretinogram Analysis of the Visual Response in Zebrafish Larvae
09:44

Electroretinogram Analysis of the Visual Response in Zebrafish Larvae

Published on: March 16, 2015

16.0K

Main Results:

  • Nof mutants showed scotopic ERGs after dark adaptation, confirming functional rods, despite lacking photopic ERGs.
  • Nof mutants exhibited reduced visual-motor responses compared to wild-type larvae, particularly under lower light intensities.
  • Dark-adapted nof mutants displayed scotopic optokinetic responses, similar to wild-type larvae.

Conclusions:

  • Functional rods are present and contribute to visual behaviors in zebrafish larvae as early as 6 dpf.
  • Scotopic visual-motor responses and optokinetic responses in 6 dpf larvae are primarily mediated by rods.