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STATUS OF PRO- AND ANTICOAGULANT COMPONENTS OF HEMOSTASIS IN PATIENTS WITH STAGE VD CKD DEPENDING ON RESIDUAL RENAL

Oleksiy B Storozhuk1, Iryna B Seleznyova2, Larysa A Storozhuk2

  • 1NATIONAL PIROGOV MEMORIAL MEDICAL UNIVERSITY, VINNYTSIA, UKRAINE.

Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|October 15, 2020
PubMed

Insights

Patients with end-stage renal disease and lost residual renal function exhibit increased risks of thrombosis due to altered hemostasis. Preserved renal function positively impacts the coagulation profile, mitigating hypercoagulation.

Area of Science:

  • Nephrology
  • Hematology
  • Clinical Chemistry

Background:

  • Chronic kidney disease (CKD) significantly impacts hemostasis.
  • End-stage renal disease (ESRD) patients on dialysis often face thrombotic complications.
  • Residual renal function (RRF) may influence the pro- and anticoagulant balance.

Purpose of the Study:

  • To investigate the hemostatic status in patients with stage V, D CKD.
  • To evaluate the role of residual renal function (RRF) in modulating hemostasis.
  • To identify key hemostatic markers associated with thrombotic risk in CKD.

Main Methods:

  • Study included 88 patients with stage V, D CKD.
  • Patients were categorized based on the presence (16 patients) or absence of RRF.
  • Hemostatic parameters measured: soluble fibrin, D-dimer, and protein C activity.

Main Results:

  • Patients with lost RRF showed elevated soluble fibrin and fibrinogen levels.
  • A decrease in D-dimer and protein C activity was observed in patients without RRF.
  • Preserved RRF was associated with a less hypercoagulable state.

Conclusions:

  • Lost RRF in stage V, D CKD is linked to increased soluble fibrin and fibrinogen, and decreased D-dimer, heightening thrombotic risk.
  • Protein C activity is significantly reduced in CKD patients who have lost RRF.
  • Maintaining RRF in stage V, D CKD positively influences the hemostatic profile.
Abstract

Keywords:
residual renal function (RRF)chronic kidney disease (CKD)hemostasis

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