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RELATIONSHIP BETWEEN PRE- AND POST-THROMBOSIS FACTORS IN PATIENTS WITH STAGE VD CKD TREATED BY LONG-TERM HEMODIALYSIS

Oleksiy B Storozhuk1, Sergiy V Shevchuk1, Larysa O Storozhuk2

  • 1NATIONAL PIROGOV MEMORIAL MEDICAL UNIVERSITY, VINNYTSIA, UKRAINE.

Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|April 4, 2021
PubMed

Insights

Accumulation of functionally inactive prothrombin forms (FIPF) signals early blood coagulation activation and potential thrombosis in hemodialysis patients. Soluble fibrin (sF) levels correlate with pre-thrombosis and post-thrombosis factors, indicating impaired anticoagulation.

Area of Science:

  • Nephrology
  • Hematology
  • Thrombosis Research

Background:

  • Patients with very dangerous (VD) stage chronic kidney disease (CKD) undergoing hemodialysis are at increased risk for thrombophilia.
  • Assessing hemostasis status in these patients is crucial for preventing thrombotic events.

Purpose of the Study:

  • To determine the informative value of pre-thrombosis, post-thrombosis, and anticoagulation factors.
  • To analyze correlations between these factors for a comprehensive assessment of hemostasis in stage VD CKD patients.

Main Methods:

  • Studied 88 patients with stage VD CKD on long-term hemodialysis.
  • Analyzed relationships between molecular markers of hemostasis, including soluble fibrin (sF), D-dimer (D-d), and functionally inactive prothrombin forms (FIPF).

Main Results:

  • Accumulation of sF correlated with D-d (r = 0.39) and FIPF (r = -0.24).
  • High sF with FIPF accumulation indicates significant pre-thrombin activation.
  • Lack of strong correlation between pre- and post-thrombosis indices suggests preserved anticoagulant capacity.

Conclusions:

  • FIPF accumulation is an early marker for coagulation activation and potential thrombosis.
  • sF levels correlate with pre- and post-thrombosis factors, linked to inhibited anticoagulation.
  • Comprehensive hemostasis assessment aids in developing prophylactic strategies against thrombophilia in stage VD CKD.
Abstract

Keywords:
D-dimerVD CKD (VD stage of chronic kidney disease)fibrinogenfunctionally inactive prothrombin formshemodialysishemostasissoluble fibrinС protein

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