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Related Concept Videos

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Related Experiment Video

Updated: Dec 5, 2025

Author Spotlight: Induced Microglia-Like Cell Technology to Shed Light on the Role of Microglial Dysfunction in Neuropsychiatric Disorders
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Microglia in depression: current perspectives.

Xiaoning Jia1,2, Zhihua Gao3,4,5, Hailan Hu6,7,8,9,10,11

  • 1Department of Psychiatry of First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.

Science China. Life Sciences
|October 17, 2020
PubMed
Summary
This summary is machine-generated.

Microglia, the brain's immune cells, are increasingly linked to major depressive disorder (MDD). This review explores how microglia dysfunction contributes to depression and may offer new therapeutic targets.

Keywords:
anti-inflammatory cytokineantidepressantdepressionketaminemicrogliamicroglial activationpro-inflammatory cytokine

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Area of Science:

  • Neuroscience
  • Immunology
  • Psychiatry

Background:

  • Major depressive disorder (MDD) is a widespread brain disorder affecting multiple cell types.
  • Microglia, the central nervous system's resident immune cells, are implicated in MDD's development and progression.
  • Stress-induced neuroinflammation involves microglia, influencing neuronal and astrocyte function.

Purpose of the Study:

  • To review the critical role of microglia in the etiology of depression.
  • To explore the dynamic states and abnormalities of microglia in depression.
  • To examine mechanisms linking microglia to depression and the impact of antidepressant therapies.

Main Methods:

  • Literature review focusing on microglia's role in depression.
  • Analysis of correlative and causal evidence for microglial involvement.
  • Discussion of stress sensing and modulation mechanisms by microglia.

Main Results:

  • Microglial abnormalities are increasingly evident in depression.
  • Microglia can modulate neuronal and astrocyte function via inflammatory mediators.
  • Antidepressant therapies may influence microglial activity.

Conclusions:

  • Microglia are key players in the pathophysiology of depression.
  • Understanding microglial roles offers potential for novel depression treatments.
  • Targeting microglia may provide new therapeutic strategies for MDD.