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Updated: Dec 5, 2025
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Published on: April 12, 2024
Functional lung imaging with synchrotron radiation: Methods and preclinical applications.
Sam Bayat1, Liisa Porra2, Pekka Suortti3
1Grenoble University Hospital, Department of Pulmonology and Clinical Physiology, France; Synchrotron Radiation for Biomedicine (STROBE) Laboratory, INSERM UA7, University of Grenoble Alps, Grenoble, France.
Synchrotron radiation imaging, including K-edge subtraction imaging, offers advanced methods to study lung diseases. This technique provides high-resolution insights into lung structure and function, aiding disease mechanism research and treatment development.
Area of Science:
- Pulmonary Medicine
- Medical Imaging
- Biophysics
Background:
- Lung diseases exhibit heterogeneity not detectable by traditional methods.
- Regional lung function analysis is vital for understanding disease and guiding treatment.
- Synchrotron radiation provides unique properties for advanced imaging.
Purpose of the Study:
- To review synchrotron radiation imaging methods for lung studies.
- To highlight applications in preclinical animal models of lung disease.
- To discuss potential clinical translation of these techniques.
Main Methods:
- Utilizing synchrotron radiation's coherence for phase-contrast imaging.
- Employing K-edge subtraction imaging (KES) for quantitative assessment.
- Applying four-dimensional (4D) imaging to study dynamic lung function and structure.
Main Results:
- Synchrotron X-ray computed tomography (CT) enables quantitative lung morphology assessment.
- Regional lung ventilation, perfusion, inflammation, and biomechanical properties can be mapped.
- Microscopic spatial resolution reveals detailed structural and functional heterogeneity.
Conclusions:
- Synchrotron radiation imaging significantly enhances the study of lung disease mechanisms.
- These advanced techniques offer potential for improved diagnosis and targeted therapies.
- Transfer of technology to laboratory X-ray sources could broaden clinical applicability.
