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Bemotrizinol-Loaded Carnauba Wax-Based Nanostructured Lipid Carriers for Sunscreen: Optimization, Characterization,
Thayse S Medeiros1,2, Lívia M C C Moreira2, Tiago M T Oliveira2
1Graduation Program in Pharmaceutical Sciences, Center for Biological and Health Sciences, Departament of Pharmacy, State University of Paraíba (UEPB), Av. Juvêncio Arruda, s/n, Bairro Universitário, Campina Grande, PB, 58429-600, Brazil.
AAPS Pharmscitech
|October 19, 2020
Summary
Nanostructured lipid carriers (NLCs) loaded with the UV filter bemotrizinol were developed for sunscreens. The optimized NLC system demonstrated enhanced photoprotective activity and stability.
Area of Science:
- Pharmaceutical Nanotechnology
- Cosmetic Science
- Materials Science
Background:
- Nanostructured lipid carriers (NLCs) are advanced drug delivery systems utilizing lipid nanoparticles.
- Sunscreens require effective UV filters with improved stability and bioavailability.
- Bemotrizinol is an organic UV filter with potential for broad-spectrum sun protection.
Purpose of the Study:
- To develop and characterize NLCs encapsulating the organic UV filter bemotrizinol for sunscreen applications.
- To optimize NLC formulation using a Box-Behnken design for controlled particle size.
- To evaluate the stability, incorporation, and in vitro photoprotective efficacy of bemotrizinol-loaded NLCs.
Main Methods:
- NLCs were prepared using carnauba wax, caprylic/capric triglycerides, and bemotrizinol via ultrasonication.
- Box-Behnken design was employed to study the effect of formulation variables on particle size.
- Particle size, morphology (SEM), thermal properties (DSC/TGA), chemical structure (FTIR), crystallinity (XRD), and in vitro photoprotection were analyzed.
Main Results:
- Optimized NLCs achieved an average particle size of 122.4 ± 0.3 nm after 30 days of storage.
- Scanning electron microscopy confirmed spherical and intact NLC particles.
- Incorporation of bemotrizinol into NLCs was confirmed by thermal and spectroscopic analyses, with reduced crystallinity observed.
- In vitro studies demonstrated enhanced photoprotective activity of bemotrizinol within the NLC system.
Conclusions:
- The developed NLC system is a promising, stable, and biocompatible platform for encapsulating bemotrizinol.
- NLC formulation significantly improves the photoprotective efficacy of the organic UV filter.
- This approach offers potential for advanced sunscreen formulations with superior UV protection.
