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Aortic aneurysm and dissection in pregnancy: A case report
Jennifer M Chin1, Marguerite L Bartholomew1
1University of Hawaii, Department of Obstetrics, Gynecology, and Women's Health, 1319 Punahou St, Ste 824, Honolulu, HI 96826, USA.
Case Reports in Women'S Health
|October 21, 2020
Summary
A pregnant woman developed a large aortic aneurysm and dissection. Genetic testing revealed a Filamin A gene variant, highlighting the need for prompt surgical intervention and genetic screening in similar cases.
Area of Science:
- Cardiovascular Medicine
- Genetics
- Obstetrics
Background:
- Aortic aneurysms and dissections are rare during pregnancy.
- Ascending aortic aneurysms can occur without typical risk factors.
Observation:
- A 24-year-old pregnant woman presented with a 6 cm ascending aortic aneurysm.
- She experienced postpartum aortic dissection and pulmonary embolism.
- A heterozygous pathogenic variant in the Filamin A gene was identified.
Findings:
- The patient underwent successful valve-sparing surgery, aortic aneurysm repair, and mechanical aortic valve replacement.
- Postpartum complications included severe preeclampsia and endometritis, delaying definitive surgical treatment.
Implications:
- Prompt surgical intervention is crucial for pregnant women with aortic aneurysms.
- A high index of suspicion and genetic testing are recommended for women with aneurysms and no known risk factors.
- Filamin A gene variants may predispose individuals to aortic aneurysms during pregnancy.
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