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Association between Serum Calcium and First Incident Acute Myocardial Infarction: A Cross-Sectional Study

Chi Zhang1, Bangming Cao1, Xingmei Huang1

  • 1Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.

Iranian Journal of Public Health
|October 21, 2020
PubMed

Insights

Lower serum calcium levels are linked to a higher risk of first acute myocardial infarction in coronary artery disease patients. This finding highlights the clinical importance of monitoring serum calcium in managing heart disease.

Area of Science:

  • Cardiology
  • Clinical Biochemistry

Background:

  • The association between serum calcium and acute myocardial infarction (AMI) in coronary artery disease (CAD) patients remains understudied.
  • This research investigates the relationship between serum calcium levels and the occurrence of first AMI in CAD patients.

Purpose of the Study:

  • To determine if serum calcium levels differ between CAD patients with and without a first incident AMI.
  • To assess the association between serum calcium and the risk of first AMI in CAD patients.

Main Methods:

  • A cross-sectional study involving 1609 cases and 3252 controls from January 2014 to December 2016.
  • Multiple logistic regression analysis was employed to evaluate the effect of serum calcium on first AMI.
  • Interactions between serum calcium and known risk factors were examined.

Main Results:

  • CAD patients experiencing a first AMI had significantly lower serum calcium concentrations compared to controls (2.18 vs. 2.24 mmol/L, P<0.0001).
  • Logistic regression revealed a significant association between serum calcium and first AMI (adjusted OR: 1.32, 95% CI: 1.22-1.42).
  • Significant interactions were observed between serum calcium and diabetes mellitus, lipoprotein (a), and serum albumin.

Conclusions:

  • Serum calcium levels are significantly associated with first incident acute myocardial infarction in coronary artery disease patients across different sexes and age groups.
  • These findings underscore the potential clinical utility of serum calcium monitoring in cardiovascular risk assessment and patient management.
Abstract

Keywords:
Acute myocardial infarctionCoronary artery diseaseCross-sectionalSerum calcium

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