Related Experiment Video

Updated: Dec 4, 2025

Direct Mouse Trauma/Burn Model of Heterotopic Ossification
07:01

Direct Mouse Trauma/Burn Model of Heterotopic Ossification

Published on: August 6, 2015

10.4K

When the Nervous System Turns Skeletal Muscles into Bones: How to Solve the Conundrum of Neurogenic Heterotopic

Kylie A Alexander1, Hsu-Wen Tseng1, Marjorie Salga2,3

  • 1Mater Research Institute, The University of Queensland, Translational Research Institute, 37 Kent Street, Woolloongabba, Queensland, 4102, Australia.

Current Osteoporosis Reports
|October 21, 2020
PubMed
Abstract

Keywords:
Central nervous systemCytokinesInflammationMacrophagesNeurogenic heterotopic ossification

More Related Videos

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas03:53

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas

Published on: October 10, 2025

259
Engineering and Characterization of an Optogenetic Model of the Human Neuromuscular Junction11:07

Engineering and Characterization of an Optogenetic Model of the Human Neuromuscular Junction

Published on: April 14, 2022

2.7K

Related Concept Videos

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
1.5K
The Neuromuscular Junction01:19

The Neuromuscular Junction

The nervous system consists of complex motor neuron circuits, including upper motor neurons originating from the cerebral cortex and lower motor neurons starting in the spinal cord, coordinating both voluntary and involuntary movements. Among these, somatic motor neurons activate skeletal muscles and are classified into alpha, beta, and gamma types. Alpha neurons are vital for voluntary movement coordination, while gamma neurons adjust muscle spindle sensitivity, and the function of beta...
16.9K
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
9.4K
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
7.5K
Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
13.1K
Gross Anatomy of Skeletal Muscles01:12

Gross Anatomy of Skeletal Muscles

The connective tissues play a significant role in arranging the muscle fibers into a hierarchical structure that forms a complete muscle. Consider a muscle like the bicep brachii, commonly called the bicep. This muscle comprises thousands of muscle fibers enclosed by a protective layer of connective tissue called the endomysium. The endomysium is primarily composed of reticular fibers, a type of thin collagen fiber. It allows the exchange of nutrients and waste products at the fiber level,...
18.1K