Label-Free Optical Resonator-Based Biosensors.

Area of Science:

• Biomedical Engineering
• Optics
• Nanotechnology

Background:

• Biosensor technology demand is rising for disease diagnosis, drug development, and environmental monitoring.
• Optical resonator biosensors provide sensitive, rapid, label-free detection of biological analytes.
• Microfluidics and micro/nanofabrication enable miniaturized, multi-analyte detection in small volumes.

Purpose of the Study:

• To review recent advancements in label-free optical resonator-based biosensors.
• To categorize biosensors into Fabry-Perot interferometer-based and whispering gallery mode-based types.
• To discuss progress in configurations, materials, test setups, and light confinement.

Main Methods:

• Literature review focusing on publications from the last 5 years.
• Categorization based on optical resonator principles: Fabry-Perot interferometers and whispering gallery modes.
• Analysis of recent developments in biosensor design and application.

Main Results:

• Optical resonator biosensors are crucial for medical diagnostics and point-of-care applications.
• Recent progress has been made in enhancing sensitivity, speed, and miniaturization.
• Both Fabry-Perot interferometer and whispering gallery mode biosensors show significant development.

Conclusions:

• Optical resonator biosensors represent a promising platform for advanced diagnostics.
• Continued research in materials and fabrication will further enhance biosensor capabilities.
• Future work should address current challenges to optimize performance and expand applications.