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Pediatric Intracranial Arteriovenous Malformation: Long-Term Outcomes with Linear Accelerator (LINAC)-Based
Ethan M Glazener1, Kenneth Lodin1, Michael J Miller1
1Department of Radiation Oncology, Kaiser Permanente, Los Angeles, California.
Advances in Radiation Oncology
|October 22, 2020
Summary
Linear accelerator-based radiosurgery (LBRS) is a safe and effective treatment for pediatric intracranial arteriovenous malformations (AVM), showing good long-term outcomes and obliteration rates in a recent study.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Pediatric Neurology
Background:
- Intracranial arteriovenous malformations (AVM) pose significant risks in pediatric patients.
- Effective long-term treatment strategies for pediatric AVM are crucial.
Purpose of the Study:
- To evaluate the long-term outcomes of pediatric patients with intracranial AVM treated with linear accelerator-based radiosurgery (LBRS).
Main Methods:
- Retrospective analysis of 34 pediatric patients (≤18 years) treated with LBRS between 2002 and 2016.
- Median LBRS dose of 16.8 Gy to the 80% isodose line.
- Analysis included patient demographics, AVM characteristics, treatment details, and follow-up outcomes.
Main Results:
- Median follow-up was 98 months.
- Sixty-four point seven percent (22/34) of AVMs achieved obliteration at a median of 37 months.
- No treatment-related deaths occurred; two patients experienced post-treatment intracranial hemorrhage, and three had symptomatic radiation necrosis.
Conclusions:
- LBRS is a safe and effective treatment modality for pediatric intracranial AVM.
- Long-term follow-up confirms the efficacy of LBRS in achieving AVM obliteration in children.
- The study supports LBRS as a viable option for managing pediatric AVMs.
