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Related Experiment Video

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Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor
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Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor

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Photoelectrochemical aptasensor with low background noise.

Yuchan Meng1, Shanshan Wang1, Jikuan Zhao1

  • 1Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, Shandong Key Laboratory of Biochemical Analysis, Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong, State Key Laboratory Base of Eco-chemical Engineering, Key Laboratory of Rubber-Plastics of Ministry of Education/Shandong Provincial Key Laboratory of Rubber Plastics, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China.

Mikrochimica Acta
|October 22, 2020
PubMed
Summary
This summary is machine-generated.

This study developed a sensitive photoelectrochemical (PEC) aptasensor for detecting breast cancer cells. The sensor utilizes carbon nanotube/tin selenide (CNT/SnSe) and a methionine-gold nanoparticle (Met-AuNPs) nanoprobe for enhanced signal and low background.

Keywords:
CNTs/SnSeCancer cellFluorescence quencherMethionineNanosheets

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Area of Science:

  • Electrochemistry
  • Nanomaterials Science
  • Biomedical Sensing

Background:

  • Enhancing photoelectrochemical (PEC) signals and reducing background noise are crucial for sensitive detection.
  • Carbon nanotube/tin selenide (CNT/SnSe) composites offer efficient electron transfer for strong PEC signals.
  • Developing selective and sensitive biosensors for early disease detection is a significant challenge.

Purpose of the Study:

  • To develop a novel PEC aptasensor for the sensitive detection of metastatic breast cancer cells.
  • To utilize CNTs/SnSe as a photoactive material and a Met-AuNPs-DNA nanoprobe as a signal quencher.
  • To investigate the mechanism of signal generation and amplification through catalytic hairpin assembly (CHA).

Main Methods:

  • Fabrication of a PEC aptasensor modified with CNTs/SnSe and a Met-AuNPs-DNA nanoprobe.
  • Utilizing catalytic hairpin assembly (CHA) triggered by cancer cell interaction with an aptamer.
  • Measuring the change in PEC signal upon release of the nanoprobe.

Main Results:

  • The developed PEC aptasensor exhibited a low blank signal and a high PEC response.
  • A linear detection range of 300–5,000 cells/mL was achieved for breast cancer cells.
  • The sensor demonstrated a low detection limit of 180 cells/mL with good reproducibility (RSD 3.6% at 10,000 cells/mL).

Conclusions:

  • The CNTs/SnSe and Met-AuNPs-based PEC aptasensor provides a promising platform for ultrasensitive detection of cancer biomarkers.
  • The strategy effectively enhances PEC signals and suppresses background noise, leading to improved sensitivity.
  • This approach holds potential for the prospective detection of various bioactive substances at ultralow concentrations.