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Deprotonative Functionalization of the Difluoromethyl Group

Laura Santos1, Armen Panossian1, Morgan Donnard1

  • 1Université de Strasbourg, Université de Haute-Alsace, CNRS, UMR 7042-LIMA, ECPM, 25 Rue Becquerel, Strasbourg 67087, France.

Organic Letters
|October 22, 2020
PubMed
Summary

Researchers developed a new method to functionalize 3-(difluoromethyl)pyridine using deprotonation and trapping. This approach yields novel silylated compounds, enabling access to diverse 3-(difluoroalkyl)pyridines.

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