Estimation of renal function using kidney dynamic contrast material-enhanced CT perfusion: accuracy and feasibility
Seokmin Jeong1, Sung Bin Park2, In Ho Chang3
1Department of Radiology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, 102, Heukseok-ro, Dongjak-gu, Seoul, 06973, Korea.
Abdominal Radiology (New York)
|October 22, 2020
Summary
Kidney dynamic contrast-enhanced (DCE)-CT perfusion scans accurately measure glomerular filtration rates (GFRs), correlating well with estimated GFRs (eGFRs). This technique offers a feasible method for assessing renal function in patients with suspected kidney disease.
Area of Science:
- Radiology
- Nephrology
- Medical Imaging
Background:
- Glomerular filtration rate (GFR) is a key indicator of kidney function.
- Accurate GFR measurement is crucial for diagnosing and managing renal diseases.
- Current estimation methods (eGFR) have limitations, necessitating more precise techniques.
Purpose of the Study:
- To evaluate kidney dynamic contrast-material enhanced (DCE)-CT perfusion scans for GFR measurement.
- To correlate GFR values derived from DCE-CT perfusion scans with estimated GFRs (eGFRs).
Main Methods:
- Split-bolus CT urography with kidney DCE-CT perfusion protocol in 55 patients.
- Continuous CT acquisition for 3.5 minutes with shallow breathing.
- Calculation of renal volume, perfusion, and permeability using dedicated software and Patlak plots for GFR determination.
Main Results:
- Mean CT-derived GFR (CT-GFR) was 91.19 ± 20.71 mL/min/1.73 m².
- No significant difference between CT-GFR and eGFRs (CKD-EPI and MDRD equations).
- Excellent correlation (r=0.91 for CKD-EPI, r=0.84 for MDRD) and agreement between CT-GFR and eGFRs.
Conclusions:
- Kidney DCE-CT perfusion is an accurate method for assessing renal function.
- This technique provides a feasible approach for GFR measurement in clinical practice.
- DCE-CT perfusion offers a reliable alternative to eGFR for evaluating kidney function.
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