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Microscopy-based Assays for High-throughput Screening of Host Factors Involved in Brucella Infection of Hela Cells

Microscopy-based Assays for High-throughput Screening of Host Factors Involved in Brucella Infection of Hela Cells

Published on: August 5, 2016

Brucellosis - laboratory workers' nightmare come true: A case study.

Lebogang Skosana¹, Farzana Ismail², Nontombi Mbelle¹

¹Department of Medical Microbiology, Tshwane Academic Division, National Health Laboratory Services, Pretoria, South Africa.

African Journal of Laboratory Medicine

|October 26, 2020

Summary

Brucella melitensis, a dangerous pathogen, can cause serious illness in laboratory workers and patients. This case highlights challenges in recognizing Brucella, managing infected patients, and preventing laboratory exposure through proper protocols and prophylaxis.

Keywords:

brucellosis laboratory exposure microbiology prophylaxis public health

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Microscopy-based Assays for High-throughput Screening of Host Factors Involved in Brucella Infection of Hela Cells

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Published on: August 5, 2016

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Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Published on: May 23, 2021

Area of Science:

Medical Microbiology
Infectious Diseases
Public Health

Background:

Brucella species are uncommon in clinical laboratories but pose significant risks to laboratory personnel.
Delayed recognition of atypical Brucella presentations can lead to delayed diagnosis and treatment.
Brucellosis outbreaks can occur due to consumption of unpasteurised dairy products.

Observation:

An 8-year-old boy from South Africa presented with a bladder mass and enuresis.
Brucella melitensis was isolated from his blood culture, leading to a diagnosis of brucellosis.
The infection was traced to the consumption of unpasteurised milk.

Findings:

The patient received a 6-week course of doxycycline and rifampicin for brucellosis.
Laboratory personnel handling the specimen were given prophylaxis due to potential exposure.
The case underscores the need for heightened awareness and preparedness for Brucella in laboratory settings.

Implications:

Improved diagnostic strategies are needed for atypical Brucella presentations.
Strict adherence to biosafety protocols is crucial when handling potentially infectious agents.
Public health interventions are essential for controlling Brucella transmission, particularly from animal sources.