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A Rat Carotid Balloon Injury Model to Test Anti-vascular Remodeling Therapeutics

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Published on: September 19, 2016

Intelligent H2S release coating for regulating vascular remodeling.

Bingyang Lu^1,2, Xiao Han^1,2, Ansha Zhao^1,2

¹Key Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu, 610031, China.

Bioactive Materials

|October 26, 2020

Summary

New pH-responsive films release hydrogen sulfide (H2S) to treat cardiovascular disease. This smart drug delivery system enhances blood vessel self-healing and offers precise treatment for atherosclerotic lesions.

Keywords:

Coronary atherosclerosis H2S Layer-by-layer self-assembly film pH responsive

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Area of Science:

Biomaterials Science
Cardiovascular Research
Drug Delivery Systems

Background:

Coronary atherosclerotic lesions present a low-pH inflammatory environment.
Current drug-eluting stents lack precise drug release control, leading to complications like delayed endothelialization and thrombosis.

Purpose of the Study:

To develop pH-responsive self-assembling films for controlled drug delivery.
To utilize a hydrogen sulfide (H2S)-releasing aspirin derivative (ACS14) for enhanced vascular function and self-healing.

Main Methods:

Hyaluronic acid and chitosan were used to create pH-responsive self-assembling films.
The films incorporated an H2S-releasing aspirin derivative (ACS14).
Evaluated drug release profiles at varying pH, blood compatibility, cellular effects, and implantation outcomes.

Main Results:

The films demonstrated pH-responsive drug release, adjusting to the lesion's microenvironment.
The released H2S promoted vascular function and self-healing, comparable to nitric oxide (NO).
Experiments confirmed favorable blood compatibility, cellular interactions, and implantation performance.

Conclusions:

This novel self-assembled film technology offers a new therapeutic concept for cardiovascular diseases.
The condition-adjusted H2S release provides a precise treatment strategy for atherosclerotic lesions.
The approach enhances blood vessel self-healing and balances vascular function.