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The Integrin Binding Peptide, ATN-161, as a Novel Therapy for SARS-CoV-2 Infection

Brandon J Beddingfield1,2, Naoki Iwanaga3, Prem P Chapagain4,5

  • 1Division of Microbiology, Tulane National Primate Research Center, Covington, Louisiana, USA.

JACC. Basic to Translational Science
|October 26, 2020
PubMed

Keywords:
ACE2ACE2, angiotensin-converting enzyme 2ATN-161CO2, carbon dioxideCOVID-19COVID-19, coronavirus disease-2019DMEM, Dulbecco’s modified eagle mediaELISA, enzyme-linked immunosorbent assayIC50, half-maximal inhibitory concentrationRBD, receptor binding domainRGD, arginine-glycine-aspartateSARS-CoV-2SARS-CoV-2, severe acute respiratory syndrome-coronavirus-2alpha5beta1 integrinhACE2, human angiotensin-converting enzyme 2host-cell entryqPCR, quantitative polymerase chain reactionreceptor binding domaintherapeuticviral spike protein

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