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Purinergic signalling in liver diseases: Pathological functions and therapeutic opportunities

Ping Wang1, Jidong Jia1, Dong Zhang2

  • 1Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis & National Clinical Research Center for Digestive Diseases, Beijing 100050, China.

JHEP Reports : Innovation in Hepatology
|October 26, 2020
PubMed

Keywords:
A1, adenosine receptor A1A2A, adenosine receptor A2AA2B, adenosine receptor A2BA3, adenosine receptor A3AIH, autoimmune hepatitisALT, alanine aminotransferaseAPAP, acetaminophenAPCP, α,β-methylene ADPAdenosine receptorsBDL, bile duct ligationCCl4, carbon tetrachlorideCD73, ecto-5ʹ-nucleotidaseConA, concanavalin ADCs, dendritic cellsDMN, dimethylnitrosamineEcto-5ʹ-nucleotidaseEctonucleoside triphosphate diphosphohydrolases 1HCC, hepatocellular carcinomaHFD, high-fat dietHGF, hepatocyte growth factorHSCs, hepatic stellate cellsIFN, interferonIL-, interleukin-IPC, ischaemic preconditioningIR, ischaemia-reperfusionLiverMAPK, mitogen-activating protein kinaseMCDD, methionine- and choline-deficient dietMHC, major histocompatibility complexNAFLD, non-alcoholic fatty liver diseaseNK, natural killerNKT, natural killer TNTPDases, ectonucleoside triphosphate diphosphohydrolasesNucleotide receptorsP1, purinergic type 1P2, purinergic type 2PBC, primary biliary cholangitisPH, partial hepatectomyPKA, protein kinase APPADS, pyridoxal-phosphate-6-azophenyl-2′,4′-disulphonatePurinergic signalsROS, reactive oxygen speciesTAA, thioacetamideTNF, tumour necrosis factorTregs, regulatory T cellsVEGF, vascular endothelial growth factor

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