Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

30.8K
Overview
30.8K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.0K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.0K
Drugs Used in Upper Respiratory Disorders: Overview01:16

Drugs Used in Upper Respiratory Disorders: Overview

499
Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
499
Asthma-I: Introduction01:29

Asthma-I: Introduction

3.1K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.1K
Upper Respiratory Drugs: First and Second-Generation Antihistamines01:15

Upper Respiratory Drugs: First and Second-Generation Antihistamines

733
Antihistamines are a class of drugs widely used to alleviate the symptoms of allergies, such as sneezing, itching, and nasal congestion. They work by inhibiting the actions of histamine, which is released by immune cells in response to allergenic substances or tissue injuries.
Histamine binds to specific receptor sites, known as H1 receptors, on tissue cells, triggering inflammation and swelling. Antihistamines combat these effects by competing with histamine for these receptor sites. By...
733
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

3.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
3.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immunonutrition in Early Life: The Role of Complementary Feeding, Dietary Patterns, and Nutritional Exposures on the Health of Young Children-An EAACI Scoping Review.

Allergy·2026
Same author

Long-Term Effect Of COVID-19 on Children's Lung Function: A Prospective Longitudinal Study.

Pediatric pulmonology·2026
Same author

Meta-Analysis on the Harm of Systemic Glucocorticosteroids in Inflammatory Upper Airway Disease and Asthma: An EAACI Task Force.

Allergy·2026
Same author

Exhaled Volatile Organic Compounds Identify Allergic Patients Among Individuals With Chronic Rhinitis.

Allergy·2026
Same author

Comorbid Chronic Rhinosinusitis and Asthma: Shared Risk Factors and Treatment Implications-An EAACI Task Force Report.

Allergy·2026
Same author

Healthcare Professional Survey on Complementary Feeding and Allergy Prevention in High- Versus Low-Risk Infants: An EAACI Task Force Report.

Allergy·2025

Related Experiment Video

Updated: Dec 3, 2025

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence
06:08

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence

Published on: September 22, 2023

2.2K

Local allergic rhinitis: a pediatric perspective.

Burçin Beken1, Ibon Eguiluz-Gracia2, Mehtap Yazıcıoğlu1

  • 1Department of Pediatric Allergy and Immunology, Trakya University Faculty of Medicine, Edirne, Turkey.

The Turkish Journal of Pediatrics
|October 27, 2020
PubMed
Summary
This summary is machine-generated.

Local allergic rhinitis (LAR) is a distinct nasal allergy affecting children, diagnosed via nasal allergen challenge without systemic signs. Recent research highlights its growing prevalence and importance in pediatric allergy diagnosis.

Keywords:
childhoodlocal allergic rhinitisnasal provocation test

More Related Videos

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

1.0K
Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

10.7K

Related Experiment Videos

Last Updated: Dec 3, 2025

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence
06:08

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence

Published on: September 22, 2023

2.2K
Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

1.0K
Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

10.7K

Area of Science:

  • Allergy and Immunology
  • Pediatric Otolaryngology
  • Clinical Rhinology

Background:

  • Local allergic rhinitis (LAR) is a specific rhinitis phenotype characterized by localized nasal symptoms without systemic atopy.
  • Diagnosis relies on a positive nasal allergen challenge (NAC) when skin prick tests and serum IgE are negative.
  • LAR is increasingly recognized, particularly in pediatric and Asian populations, with a growing body of recent literature.

Purpose of the Study:

  • To review recent literature on pediatric Local Allergic Rhinitis (LAR).
  • To aid in the clinical identification and diagnosis of LAR in children lacking systemic atopy.
  • To update knowledge on the prevalence, diagnosis, and triggers of LAR in pediatric populations.

Main Methods:

  • Systematic review of recent scientific literature focusing on pediatric Local Allergic Rhinitis (LAR).
  • Analysis of studies reporting diagnosis via nasal allergen challenge (NAC).
  • Inclusion of data on prevalence, seasonal/perennial patterns, and specific allergen triggers in children.

Main Results:

  • The prevalence of LAR in children varies widely (3.7%–66.6%), with higher rates in Western countries.
  • LAR in children can be seasonal or perennial, triggered by allergens like house dust mites, pollens, molds, and dander.
  • A significant proportion of children experience the onset of nasal symptoms during childhood.

Conclusions:

  • Local Allergic Rhinitis (LAR) is a crucial differential diagnosis for children presenting with presumed non-allergic rhinitis.
  • Recent literature supports the growing evidence and importance of LAR in pediatric allergy.
  • Accurate diagnosis through NAC is essential for effective management of pediatric LAR.