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[Mumps virus: a comprehensive review].

Thomas Mourez1, Julia Dina2

  • 1Normandie Univ, UniRouen, EA2656, CHU de Rouen, Laboratoire de Virologie, 1 rue de Germont, 76031 Rouen, France.

Virologie (Montrouge, France)
|October 28, 2020
PubMed
Summary
This summary is machine-generated.

Mumps virus infections are now rare in children due to vaccination, but adult cases are increasing. Long-term vaccine effectiveness is questioned, potentially requiring updated recommendations for mumps eradication.

Keywords:
mumps virusparamyxoviridaeparotitisvaccination

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Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Mumps virus (Paramyxoviridae family) causes diverse pathologies like parotitis, orchitis, and meningitis.
  • Vaccination has significantly reduced mumps incidence in children globally.
  • Increased proportion of adult infections observed due to lower virus circulation.

Purpose of the Study:

  • To analyze the current epidemiology of mumps virus infections.
  • To evaluate the long-term effectiveness of mumps vaccination.
  • To discuss potential future vaccination strategies for mumps eradication.

Main Methods:

  • Surveillance of mumps virus infections at national and international levels.
  • Molecular-level monitoring of viral circulation.
  • Analysis of vaccination effectiveness and population immunity trends.

Main Results:

  • Mumps is now rarer in children due to widespread vaccination programs.
  • A notable increase in adult mumps cases has been observed.
  • Concerns exist regarding the waning long-term effectiveness of current mumps vaccines.

Conclusions:

  • The decrease in immunity over time may be linked to vaccine strains and lack of natural viral stimulation.
  • Updated vaccination recommendations may be necessary for sustained mumps control and potential eradication.
  • Continued surveillance, especially molecular, is crucial for monitoring mumps virus trends.