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Updated: Dec 3, 2025
10:10
Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
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Applications of NMR in Drug:Cyclodextrin Complexes
Dimitrios Ntountaniotis1, Georgios Leonis2, Eirini Christodoulou2
1Chemistry Department, Laboratory of Organic Chemistry, National Kapodistrian University of Athens, Athens, Greece. doudaniotis@yahoo.gr.
Methods in Molecular Biology (Clifton, N.J.)
|October 28, 2020
Summary
Nuclear Magnetic Resonance (NMR) spectroscopy offers detailed insights into drug delivery systems. Advanced NMR techniques enhance the study of drug:cyclodextrin complexes, revealing structural and dynamic properties.
Area of Science:
- Biophysical Chemistry
- Materials Science
- Pharmaceutical Sciences
Background:
- Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful tool for characterizing materials at atomic resolution.
- Technological advancements in NMR instrumentation and scientific understanding have expanded its applications.
- Studying drug delivery systems and bioactive materials requires detailed structural and dynamic information.
Purpose of the Study:
- To highlight the utility of NMR spectroscopy in analyzing drug:cyclodextrin complexes.
- To showcase applications using both liquid-state and solid-state NMR techniques.
- To provide a comprehensive overview of NMR's role in understanding these complexes.
Main Methods:
- Liquid-state NMR spectroscopy
- Solid-state NMR spectroscopy
- Structural elucidation
- Dynamic characterization
Main Results:
- NMR provides atomic-level resolution of structural and dynamic characteristics.
- Applications in drug:cyclodextrin complexes are significantly enhanced by modern NMR.
- Both liquid- and solid-state NMR offer complementary data for complex analysis.
Conclusions:
- NMR spectroscopy is indispensable for detailed analysis of drug:cyclodextrin interactions.
- Advancements in NMR technology continue to broaden its scope in pharmaceutical research.
- This chapter demonstrates the versatility of NMR in characterizing complex drug delivery systems.
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