Miscibility Studies of Hyaluronic Acid and Poly(Vinyl Alcohol) Blends in Various Solvents

In this study, blends based on hyaluronic acid (HA) and poly(vinyl alcohol) (PVA) were characterized by the viscometric method, steady shear rheological tests and FTIR spectroscopy (Fourier Transform Infrared Spectroscopy). Viscometric studies showed the miscibility of HA and PVA in distilled water: 0.1 mol dm^-3 NaCl and 0.1 mol dm^-3 HCl. The method proposed by Garcia et al. was applied to assess the miscibility of polymers, while Δ[η] and Δb were introduced to determine of miscibility from the Huggins plots. The viscometric data showed that the attractive forces of HA and PVA were dominant when dissolved in 0.1 mol dm^-3 NaCl and 0.1 mol dm^-3 HCl, while, in distilled water, repulsive forces played the leading role. All polymer solutions were well characterized using a power law model, and exhibited non-Newtonian behavior with pseudoplasticity increasing with the increasing weight fraction of HA in 0.1 mol dm^-3 NaCl and 0.1 mol dm^-3 HCl. FTIR studies exhibited the formation of new intermolecular interactions between HA and PVA via hydrogen bonding.