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SARS-CoV-2 infection in a patient with propionic acidemia
Anna Caciotti1, Elena Procopio2, Francesca Pochiero2
1Molecular and Cell Biology Laboratory, Paediatric Neurology Unit and Laboratories, Neuroscience Department, A. Meyer Children's Hospital, Viale Pieraccini n. 24, 50139, Florence, Italy.
Orphanet Journal of Rare Diseases
|October 29, 2020
Summary
A child with propionic acidemia (PA) experienced his first metabolic crisis due to SARS-CoV-2 infection, presenting a mild COVID-19 course. This case highlights SARS-CoV-2 impact on inborn errors of metabolism in children.
Area of Science:
- Pediatrics
- Infectious Diseases
- Metabolic Disorders
Background:
- Propionic acidemia (PA) is an inborn error of metabolism diagnosed via newborn screening, carrying a high risk of metabolic crises.
- Children with comorbidities, particularly inborn errors of metabolism, have limited reported cases of SARS-CoV-2 infection.
Observation:
- A 14-month-old boy with diagnosed PA presented with a suspected metabolic crisis and tested positive for SARS-CoV-2.
- Despite the PA diagnosis and SARS-CoV-2 infection, the child exhibited normal psychomotor development prior to the crisis.
Findings:
- SARS-CoV-2 infection precipitated the patient's first metabolic crisis at approximately one year of age.
- The COVID-19 illness was mild, with the patient recovering without severe clinical consequences.
Implications:
- This case contributes to understanding the follow-up care for PA patients identified through newborn screening.
- It expands the limited data on SARS-CoV-2 infection outcomes in children with inborn errors of metabolism.
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