[Sickle cell disease and pregnancy]

Area of Science:

• Hematology
• Obstetrics
• Genetics

Background:

• Sickle cell disease (SCD) is a prevalent severe hereditary blood disorder globally.
• Pregnancy with SCD increases risks for maternal and fetal complications, including mortality and fetal growth restriction.
• Increased migration has led to a rise in pregnant women with SCD in regions like Denmark.

Purpose of the Study:

• To review the etiology, assessment, antenatal care, and treatment of pregnant women with SCD.
• To provide guidance for managing SCD in pregnancy.

Main Methods:

• Literature review focusing on SCD in pregnancy.
• Synthesis of current knowledge on SCD management during gestation.

Main Results:

• SCD in pregnancy is linked to significant adverse perinatal outcomes.
• Comprehensive antenatal care and timely interventions are crucial for improving outcomes.
• Management requires a multidisciplinary approach.

Conclusions:

• Pregnant women with SCD require specialized, multidisciplinary care.
• Early diagnosis and proactive management can mitigate risks associated with SCD during pregnancy.
• Further research is needed to optimize care protocols.