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Polymeric Microneedle Array Fabrication by Photolithography
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Microneedles: Characteristics, Materials, Production Methods and Commercial Development.

Amina Tucak1, Merima Sirbubalo1, Lamija Hindija1

  • 1Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina.

Micromachines
|October 30, 2020
PubMed
Summary

Microneedles (MNs) offer a minimally invasive way to deliver drugs through the skin, overcoming limitations of traditional transdermal drug delivery systems (DDS). This review covers MN characteristics, materials, and production for diverse applications.

Keywords:
coating techniquesmaterialsmicroneedle arraysmicroneedlesmicroscale fabrication techniquestransdermal drug delivery

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Pharmaceutical Sciences

Background:

  • Transdermal drug delivery systems (DDS) offer advantages like avoiding gastric irritation and first-pass metabolism, improving patient compliance.
  • However, only a limited number of active pharmaceutical ingredients (APIs) are suitable for traditional DDS.
  • Microneedles (MNs) have emerged as a promising technology for effective transdermal delivery, penetrating the skin barrier minimally invasively.

Purpose of the Study:

  • To provide a comprehensive overview of microneedle (MN) characteristics.
  • To review material compositions used in MN fabrication.
  • To discuss the production methods and commercial development of MN-based drug and vaccine delivery systems.

Main Methods:

  • Review of existing literature on microneedle technology.
  • Analysis of different manufacturing techniques for MNs and their molds.
  • Examination of material science aspects relevant to MNs.
  • Survey of commercialization trends and applications.

Main Results:

  • Microneedles enable painless and minimally invasive transdermal drug delivery.
  • Various manufacturing methods allow cost-effective production of MNs.
  • MN technology is evolving for drug delivery, vaccinations, and diagnostics.

Conclusions:

  • Microneedles represent a significant advancement in transdermal drug delivery systems.
  • Continued innovation in materials and manufacturing is driving the commercial development of MN-based products.
  • MNs offer a versatile platform for various biomedical applications beyond drug delivery.