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Carbonylative C-C Bond Activation of Aminocyclopropanes Using a Temporary Directing Group Strategy
Gang-Wei Wang1, Olga O Sokolova1, Tom A Young2
1School of Chemistry, University of Bristol, Bristol, BS8 1TS, United Kingdom.
Abstract:
Temporary directing groups (TDGs) underpin a range of C-C bond activation methodologies; however, the use of TDGs for the regiocontrolled activation of cyclopropane C-C bonds is underdeveloped. In this report, we show how an unusual ring contraction process can be harnessed for TDG-based carbonylative C-C bond activations of cyclopropanes. The method involves the transient installation of an isocyanate-derived TDG, rather than relying on carbonyl condensation events as used in previous TDG-enabled C-C bond activations.
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