COMMON VARIABLE IMMUNODEFICIENCY AMONG KYIV RESIDENTS: HETEROGENEITY OF MANIFESTATIONS (CLINICAL CASE REVIEW)

Common variable immunodeficiency (CVID) is a kind of hypoimmunoglobulinemia of different spectrum with a dominant decrease of IgG with heterogeneity of clinical manifestations. In this publication, we provide an analysis of some world research sources on the diagnosis and treatment of the CVID and description of a clinical case of the CVID and the structural analysis of its frequency among primary immunodeficiencies in the adult population. We described the clinical case that demonstrates unusual manifestation of adult's outcome of CVID with cellular immune deficiencies and immunoglobulin А deficiency and RAG-2 gene mutation. There is the prevalence of CVID and hereditary hypo-/agammaglobulinemias among the primary diagnosed immunodeficiencies in the inhabitants of the Kyiv region, that is given the severity of clinical manifestations and need of replacement immunoglobulinotherapy. As early prognostic marker for the development of CVID and other defects of antibodies an immunoglobulin E deficiency can be considered.