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Resistance in Vancomycin-Resistant Enterococci

William R Miller1, Barbara E Murray2, Louis B Rice3

  • 1Department of Internal Medicine, Division of Infectious Diseases, University of Texas Health Science Center at Houston, McGovern Medical School, 6431 Fannin St. MSB 2.112, Houston, TX 77030, USA; Center for Antimicrobial Resistance and Microbial Genomics (CARMiG).

Infectious Disease Clinics of North America
|November 2, 2020
PubMed

Insights

Serious infections from vancomycin-resistant enterococci (VRE) remain challenging despite new antibiotics. Understanding resistance emergence and colonization is key for better clinical management of these difficult hospital-associated pathogens.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Pharmacology

Background:

  • Serious infections caused by vancomycin-resistant enterococci (VRE) present significant clinical challenges.
  • Treatment often requires combination therapy and careful management of toxicity.
  • Despite new antibiotic options, VRE infections remain difficult to treat.

Purpose of the Study:

  • To highlight the persistent challenges in managing vancomycin-resistant enterococci infections.
  • To emphasize the need for a deeper understanding of VRE resistance and colonization.
  • To prepare clinicians for tackling these hospital-associated pathogens more effectively.

Main Methods:

  • Review of current literature on vancomycin-resistant enterococci.
  • Analysis of factors contributing to resistance emergence.
  • Examination of gastrointestinal colonization dynamics and microbiota-mediated resistance.
  • Investigation of resistance mechanisms against available therapeutics.

Main Results:

  • Vancomycin-resistant enterococci infections continue to be a major clinical concern.
  • New antibiotics have been introduced, but significant therapeutic challenges persist.
  • Understanding resistance drivers and colonization is crucial for effective treatment.

Conclusions:

  • A comprehensive understanding of VRE resistance mechanisms and colonization is essential.
  • This knowledge will better equip clinicians to manage VRE infections.
  • Improved preparedness is vital for combating these challenging hospital-associated pathogens.
Keywords:
Colonization resistanceMechanisms of resistanceVREVRE colonizationVancomycin resistant enterococcus

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