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Related Concept Videos

Brain Imaging01:14

Brain Imaging

521
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
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Positron Emission Tomography01:29

Positron Emission Tomography

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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
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Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

349
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
349

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Related Experiment Video

Updated: Dec 2, 2025

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG
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PET Imaging as a Tool for Assessing COVID-19 Brain Changes.

Igor C Fontana1, Salvatore Bongarzone2, Antony Gee2

  • 1Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; School of Biomedical Engineering and Imaging Sciences, St Thomas' Hospital, King's College London, London SE1 7EH, UK.

Trends in Neurosciences
|November 2, 2020
PubMed
Summary

Neurological issues are common in COVID-19 patients, but SARS-CoV-2 brain changes are unclear. Positron emission tomography (PET) scans can help reveal central nervous system (CNS) alterations in COVID-19.

Keywords:
PET radiotracersSARS-CoV-2neurological manifestations

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Area of Science:

  • Neuroscience
  • Infectious Diseases
  • Medical Imaging

Background:

  • A significant number of patients with coronavirus disease 2019 (COVID-19) present with neurological symptoms.
  • The specific brain alterations induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are not well understood.
  • Understanding these changes is crucial for managing neurological complications of COVID-19.

Purpose of the Study:

  • To provide an overview of how positron emission tomography (PET) can be utilized.
  • To explore the potential of PET applications in elucidating central nervous system (CNS) pathophysiological changes in SARS-CoV-2 infection.
  • To highlight PET's role in advancing the understanding of neuro-COVID-19.

Main Methods:

  • Review of current literature on PET imaging techniques.
  • Discussion of established PET tracers and their relevance to neuroinflammation, metabolism, and receptor occupancy.
  • Exploration of novel PET strategies for studying viral infections in the brain.

Main Results:

  • PET imaging offers a non-invasive method to visualize and quantify biological processes in the brain.
  • Specific PET tracers can detect neuroinflammation, altered glucose metabolism, and changes in neurotransmitter systems relevant to neurological manifestations.
  • PET can potentially differentiate between direct viral effects, indirect inflammatory responses, and secondary complications in the CNS.

Conclusions:

  • Positron emission tomography presents a powerful tool for investigating the neurological impact of SARS-CoV-2.
  • PET applications can significantly enhance our comprehension of the underlying brain pathophysiology in COVID-19.
  • Further research utilizing PET is warranted to fully characterize CNS alterations and guide therapeutic strategies for neuro-COVID-19.