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Immunoneutralization of circulating pancreatic polypeptide and pancreatic secretion
S J Konturek1, W Bielański, N Kwiecień
1Institute of Physiology, Medical Academy, Kraków, Poland.
Pancreas
|January 1, 1987
Summary
This study investigated pancreatic polypeptide (PP) as an inhibitor of pancreatic secretion. Results show endogenous PP does not physiologically inhibit pancreatic secretion, contrary to previous suggestions.
Area of Science:
- Gastroenterology
- Endocrinology
- Physiology
Background:
- Pancreatic polypeptide (PP) is a hormone released from endocrine cells in the pancreas.
- Previous research suggested PP might inhibit pancreatic secretion.
Purpose of the Study:
- To determine the physiological role of endogenous pancreatic polypeptide (PP) in regulating pancreatic secretion.
Main Methods:
- Dogs with chronic fistulas received PP antiserum or normal rabbit serum.
- Pancreatic secretion was measured during sham-feeding and after meat meal ingestion.
- Plasma levels of PP and gastrin were monitored.
Main Results:
- Endogenous PP release increased with feeding and correlated with pancreatic secretion.
- Neutralizing endogenous PP did not significantly alter gastric acid or pancreatic secretion responses.
- PP antiserum partially blocked the inhibitory effect of exogenous PP on stimulated pancreatic secretion.
Conclusions:
- Endogenous pancreatic polypeptide (PP) does not act as a physiological inhibitor of exocrine pancreatic secretion.
- The findings challenge previous hypotheses regarding PP's inhibitory role.