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Updated: Dec 2, 2025

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Recent advances in 1,4-functional group migration-mediated radical fluoroalkylation of alkenes and alkynes
Ya-Jing Chen1, Ya-Li Qu1, Xiang Li2
1School of Pharmaceutical Sciences, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education of China; Co-innovation Center of Henan Province for New Drug R&D and Preclinical Safety, Zhengzhou University, 100 Science Avenue, Zhengzhou 450001, Henan, PR China. chenyj@zzu.edu.cn.
Abstract:
Recently, the combination of radical fluoroalkylation of alkenyl or alkynyl moieties and 1,4-functional group migration (1,4-FGM) has emerged as a powerful strategy for the synthesis of fluorine-containing compounds. In this article, some representative reactions of 1,4-FGM-mediated radical fluoroalkylation of N-(arylsulfonyl)acrylamides, tertiary alcohol-containing alkynes, tertiary alcohol-containing alkenes and intermolecular 1,4-FGM-type substrates have been discussed based on the types of substrates.
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