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Inflammation-driven vascular dysregulation in chronic rhinosinusitis
Nitish Khurana1,2, Abigail Pulsipher2,3, Jolanta Jedrzkiewicz4
1Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT.
International Forum of Allergy & Rhinology
|November 2, 2020
Summary
Chronic rhinosinusitis (CRS) involves increased blood vessel growth and permeability. These vascular changes suggest inflammation-driven dysregulation, impacting sinonasal tissue drug delivery.
Area of Science:
- Immunology
- Vascular Biology
- Otolaryngology
Background:
- Chronic inflammatory diseases share pathophysiology with chronic rhinosinusitis (CRS).
- Vascular changes in CRS are not well-characterized.
- Understanding vascular alterations is key for developing targeted drug-delivery technologies in CRS.
Purpose of the Study:
- To characterize angiogenesis and vascular permeability in chronic rhinosinusitis (CRS).
- To investigate the role of vascular dysregulation in CRS pathology.
Main Methods:
- Prospective, observational study of CRS patients (CRSwNP, CRSsNP) and controls.
- Immunohistochemistry and gene expression analysis for angiogenesis.
- Transmission electron microscopy for vascular permeability and endothelial morphology.
Main Results:
- Increased sinonasal vascularity (PECAM-1 positive vessels) in CRSsNP and CRSwNP compared to controls (p < 0.05).
- Elevated pro-angiogenic gene expression (PECAM1, PAFR) in CRSwNP.
- Larger endothelial fenestration sizes in CRSwNP and CRSsNP compared to controls, indicating increased vascular permeability.
Conclusions:
- CRS exhibits significant increases in vascularity, pro-angiogenic factors, and blood vessel morphogenesis.
- Enhanced endothelial fenestration suggests inflammation-driven vascular dysregulation in CRS.
- Findings support targeting vascular changes for improved therapeutic strategies in CRS.
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