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Osteogenesis Differences Around Titanium Implant and in Bone Defect Between Jaw Bones and Long Bones.
Li-Nan Liu1, Xiao-Hui Zhang, Hang-Hang Liu
1State Key Laboratory of Oral Disease & National Clinical Research Center for Oral Diseases & Department of Oral Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, People's Republic of China.
The Journal of Craniofacial Surgery
|November 2, 2020
Summary
Ovariectomized (OVX) rats showed decreased bone healing around titanium implants and in bone defects in long bones. However, OVX had minimal impact on jaw bone healing, suggesting localized effects of osteoporosis on bone regeneration.
Area of Science:
- Biomedical Engineering
- Orthopedics
- Osteoporosis Research
Background:
- Osteoporosis, often induced by ovariectomy (OVX), is a condition characterized by reduced bone density and impaired bone quality.
- Titanium implants are widely used in orthopedic and dental applications, and their osseointegration is crucial for successful outcomes.
- Bone defects and fractures require effective bone regeneration for healing, which can be compromised by systemic conditions like osteoporosis.
Purpose of the Study:
- To evaluate the impact of OVX-induced osteoporosis on osteogenesis around titanium implants.
- To assess the effect of OVX on bone healing in defects and fractures of jaw and long bones.
- To compare the regenerative capacity of bone in OVX versus sham-operated animal models.
Main Methods:
- A literature review of 52 articles was conducted, analyzing osteogenesis around titanium implants and in bone defects/fractures.
- An experimental study utilized 48 rats, divided into OVX and SHAM groups.
- Titanium implants and bone defects were created in the mandibles and tibiae of rats, followed by Micro-CT and histological analysis at 2 and 4 weeks post-surgery.
Main Results:
- Literature review indicated a need for further investigation into OVX effects on bone regeneration.
- Experimental results showed significantly decreased osteogenesis around titanium implants and in bone defects in the tibiae of OVX rats compared to SHAM rats.
- No statistically significant differences in osteogenesis were observed in the mandible between OVX and SHAM groups.
Conclusions:
- OVX-induced osteoporosis significantly suppresses osteogenesis and bone regeneration in long bones, affecting both implant osseointegration and fracture healing.
- Jaw bones appear to be less affected by OVX-induced osteoporosis compared to long bones in terms of osteogenesis.
- These findings highlight the differential impact of osteoporosis on bone healing in different skeletal sites, with implications for treatment strategies involving implants and bone repair.
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