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Preoperative prognostic nutritional index predicts risk of recurrence after curative resection for stage IIA colon
Tsunehiko Maruyama1, Mitsugi Shimoda2, Hiroyuki Hakoda3
1Department of Surgery, Mito Saiseikai General Hospital, Japan; Department of Gastroenterological Surgery, Ibaraki Medical Center, Tokyo Medical University, Japan.
Background:
Preoperative nutritional and inflammatory indices have been reported to be associated with the prognosis of patients with malignancy. We evaluated clinicopathological factors, including nutritional and inflammatory indices, and recurrence prognosis in patients with stage IIA colon cancer (CC) who underwent curative surgery.
Methods:
This retrospective study included 197 patients with stage IIA CC who had undergone curative resection. We evaluated the association between prognostic nutritional index (PNI), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) with clinicopathological factors and prognosis for recurrence. For the recurrence-free survival (RFS) analysis, receiver operating characteristic (ROC) curves were used to determine appropriate cutoff values for PNI, NLR, and PLR.
Results:
Univariate analyses showed that PNI<44.8 (P = 0.028) was significantly associated with worse RFS in patients with stage IIA CC patients. In the multivariate analyses, PNI<44.8 (hazard ratio [HR] 2.082; 95% confidence interval [CI] 1.005-4.317; P = 0.049) independently and significantly predicted RFS.
Conclusion:
PNI is a useful marker for predicting recurrence prognosis in post-resection patients with stage IIA CC.
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