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Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
Published on: April 21, 2017
Perinatal Arterial Ischemic Stroke
1Division of Pediatric Hematology-Oncology, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Insights
Perinatal arterial ischemic stroke (PAIS) is a significant cause of neonatal neurological issues and cerebral palsy. Early detection and intervention are crucial for managing PAIS and improving long-term outcomes.
Area of Science:
- Neonatal neurology
- Pediatric stroke research
Background:
- Perinatal arterial ischemic stroke (PAIS) is a frequent cause of neonatal seizures, encephalopathy, and focal neurologic deficits.
- PAIS is the primary known cause of cerebral palsy, with significant long-term risks.
- Associated long-term risks include epilepsy, and impairments in cognition, language, and behavior.
Purpose of the Study:
- To review the known risk factors for perinatal arterial ischemic stroke.
- To outline the current evaluation and management strategies for PAIS.
- To discuss the prognosis and long-term neurodevelopmental outcomes following PAIS.
Main Methods:
- Literature review of perinatal arterial ischemic stroke.
- Synthesis of information on risk factors, clinical presentation, and diagnostic approaches.
- Compilation of current management guidelines and prognostic indicators.
Main Results:
- Identified common risk factors associated with PAIS.
- Detailed the typical clinical manifestations and diagnostic workup for neonatal stroke.
- Summarized treatment modalities and their impact on patient outcomes.
- Highlighted the importance of long-term neurodevelopmental surveillance.
Conclusions:
- PAIS presents with diverse neurological symptoms in neonates and is a leading cause of cerebral palsy.
- Comprehensive evaluation, prompt management, and intensive therapies are essential for reducing PAIS morbidity.
- Long-term neurodevelopmental surveillance is recommended for affected individuals to monitor and address developmental challenges.
Abstract:
Perinatal arterial ischemic stroke (PAIS) is a common cause of seizures, encephalopathy, altered mental status, and focal neurologic deficits in the neonatal period. It is the leading known cause of cerebral palsy. Other long-term risks include the development of epilepsy and impairment in cognition, language, and behavior. This article will review the known risk factors for PAIS, as well as the evaluation, management, and prognosis. Long-term neurodevelopmental surveillance is recommended, along with intensive therapies to reduce morbidity.
