Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

171
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
171
Classification of Illness01:17

Classification of Illness

8.3K
The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
8.3K
Multiple Allele Traits01:49

Multiple Allele Traits

37.2K
The Concept of Multiple Allelism
37.2K
Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

449
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
449
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

332
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
332
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

3.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
3.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessing the abuse liability of U.S. Food and Drug Administration-authorized electronic nicotine delivery systems: Impact of nicotine flux, flavor, and menthol cigarette smoking status.

Experimental and clinical psychopharmacology·2026
Same author

Evaluating high-sensitivity troponin levels in people with sickle cell disease in the emergency department.

British journal of haematology·2026
Same author

A Qualitative Phenomenological Study of Treatment Options for Patients with SCD and Chronic Pain: Buprenorphine-Naloxone or Full-Agonist Therapy.

International journal of environmental research and public health·2026
Same author

Ciliary protein ARL13b detected on RBCs as a potential indicative biomarker of vaso-occlusive crisis and disease severity in SCD: a retrospective pilot study.

Journal of sickle cell disease·2026
Same author

Cytokine Profiling of Systemic Sclerosis-Related Pulmonary Hypertension.

Arthritis & rheumatology (Hoboken, N.J.)·2026
Same author

Many uncertainties remain in the long-term care of sickle cell disease-pulmonary hypertension.

American journal of respiratory and critical care medicine·2026

Related Experiment Video

Updated: Dec 2, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

1.8K

Development of a Severity Classification System for Sickle Cell Disease.

Nirmish Shah1, David Beenhouwer2, Michael S Broder2

  • 1Department of Medicine, Duke University, Durham, NC, USA.

Clinicoeconomics and Outcomes Research : CEOR
|November 5, 2020
PubMed
Summary

A new 3-level classification system for sickle cell disease (SCD) severity was developed to predict clinical outcomes. This system groups patients based on organ damage and acute care visits, aiding clinical decision-making.

Keywords:
chronic paindisease severityexpert panelorgan damagevaso-occlusive crises

More Related Videos

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

10.2K
Magnetic Levitation Coupled with Portable Imaging and Analysis for Disease Diagnostics
07:42

Magnetic Levitation Coupled with Portable Imaging and Analysis for Disease Diagnostics

Published on: February 19, 2017

9.1K

Related Experiment Videos

Last Updated: Dec 2, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

1.8K
Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

10.2K
Magnetic Levitation Coupled with Portable Imaging and Analysis for Disease Diagnostics
07:42

Magnetic Levitation Coupled with Portable Imaging and Analysis for Disease Diagnostics

Published on: February 19, 2017

9.1K

Area of Science:

  • Hematology
  • Clinical Medicine
  • Disease Classification

Background:

  • Sickle cell disease (SCD) lacks a universally accepted severity classification.
  • Accurate SCD severity assessment is crucial for predicting clinical outcomes and guiding treatment.

Purpose of the Study:

  • To develop and test a novel classification system for overall sickle cell disease severity.
  • The system aims to serve as a reliable clinical outcome predictor.

Main Methods:

  • A modified Delphi panel approach involving 10 multidisciplinary expert clinicians was employed.
  • Experts rated 180 simplified patient histories on disease severity, quality of life, and risk of complications.
  • A 3-level severity classification (Class I to Class III) was derived from overall disease severity ratings.

Main Results:

  • Class I patients exhibit minimal or no end-organ damage, chronic pain, and limited acute care visits for vaso-occlusive crises (VOC).
  • Class III patients present with significant end-organ damage and/or frequent acute care visits (≥5 per year).
  • Class II encompasses patients not meeting Class I or III criteria, with specific exceptions for retinopathy.

Conclusions:

  • The developed 3-level system effectively categorizes patients into homogeneous groups based on SCD severity.
  • The classification aligns with established knowledge linking increased acute care visits and organ damage to patient morbidity.
  • Further validation studies are planned to confirm the system's utility in clinical practice.