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Neuroimmune Communication in the Kidney
Yasuna Nakamura1, Tsuyoshi Inoue2
1Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
JMA Journal
|November 5, 2020
Summary
The cholinergic anti-inflammatory pathway (CAP) uses vagus nerve stimulation to reduce inflammation by releasing neurotransmitters. This pathway shows promise for treating kidney disease and other inflammatory conditions.
Area of Science:
- Neuroimmunology
- Nephrology
Background:
- The cholinergic anti-inflammatory pathway (CAP) regulates inflammation via vagus nerve stimulation.
- This pathway involves immune cells in the spleen releasing neurotransmitters to reduce proinflammatory cytokines.
Purpose of the Study:
- To review the neuroimmune circuit's role in kidney disease.
- To explore therapeutic strategies for kidney disease based on neuroimmune interactions.
Main Methods:
- Review of current scientific literature on the cholinergic anti-inflammatory pathway.
- Analysis of studies investigating vagus nerve stimulation in kidney injury models.
Main Results:
- CAP activation reduces inflammation by modulating immune cell responses.
- Vagus nerve stimulation has demonstrated potential in ameliorating kidney damage in animal models.
Conclusions:
- The neuroimmune axis is implicated in the pathophysiology of kidney disease.
- Targeting the neuroimmune circuit offers potential therapeutic avenues for clinical kidney disease treatment.
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