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Updated: Dec 2, 2025
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Roux-en-Y Gastric Bypass Operation in Rats
Published on: June 11, 2012
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Gut Mucosal Gene Expression and Metabolic Changes After Roux-en-Y Gastric Bypass Surgery
Tina Jorsal1, Marie M Christensen1,2, Brynjulf Mortensen1
1Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
Obesity (Silver Spring, Md.)
|November 5, 2020
Summary
Roux-en-Y gastric bypass (RYGB) surgery significantly alters gut hormone secretion and gene expression, leading to improved metabolic health. These changes in gut hormones and gene expression may offer new therapeutic targets for obesity and diabetes.
Area of Science:
- Gastroenterology
- Metabolic Surgery
- Molecular Biology
Background:
- Roux-en-Y gastric bypass (RYGB) is linked to metabolic improvements.
- Changes in gut-derived peptide hormones are associated with RYGB's benefits.
Purpose of the Study:
- To evaluate RYGB's effects on anthropometrics, hormone responses, and gene expression.
- To investigate changes in small intestinal mucosa before and after RYGB.
Main Methods:
- Cross-sectional study of 20 individuals with obesity undergoing RYGB.
- Mixed meal tests and upper enteroscopy for biopsy retrieval.
- Analysis of plasma hormone concentrations and mRNA sequencing.
Main Results:
- RYGB improved body weight, composition, insulin resistance, and cholesterol levels.
- Significant alterations in postprandial plasma gut and pancreatic hormone responses were observed.
- Global gene expression analysis revealed 2,437 differentially expressed genes, including those for prohormones and G protein-coupled receptors.
Conclusions:
- RYGB influences the transcription of numerous genes in the gut.
- Beneficial metabolic effects of RYGB may stem from altered gene expression.
- Changes in signaling peptide and G protein-coupled receptor genes suggest new therapeutic targets for obesity and diabetes.
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