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Related Concept Videos

Obsessive-Compulsive Disorder01:28

Obsessive-Compulsive Disorder

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Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
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Oppositional Defiant Disorder01:30

Oppositional Defiant Disorder

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A persistent pattern of angry or irritable mood, defiant behavior, or vindictiveness characterizes Oppositional Defiant Disorder (ODD). Symptoms must occur over at least six months, involve interactions with individuals beyond siblings, and meet specific diagnostic criteria to be clinically significant. The disorder affects emotional regulation, social interactions, and behavior, often manifesting early in life and influencing long-term development and functioning.
Diagnostic Criteria and...
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Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

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Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
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To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
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Personality Disorders: Dependent and Obsessive-Compulsive01:24

Personality Disorders: Dependent and Obsessive-Compulsive

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Dependent personality disorder and obsessive-compulsive personality disorder are two separate psychological conditions that influence behavior, relationships, and overall life functioning. Though both involve maladaptive behaviors, their core characteristics and motivations differ significantly.
 Dependent Personality Disorder
Dependent personality disorder is characterized by an excessive reliance on others to manage various aspects of life. Individuals with this disorder often struggle...
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Brain Imaging01:14

Brain Imaging

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Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
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Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

299
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
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Related Experiment Video

Updated: Dec 2, 2025

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

650

Developmental Neuroimaging in Pediatric Obsessive-Compulsive Disorder.

Yanni Liu1, Emily L Bilek1, Kate D Fitzgerald1

  • 1Department of Psychiatry, University of Michigan Medical School. 4250 Plymouth Road, Ann Arbor, MI, 48109.

Current Behavioral Neuroscience Reports
|November 6, 2020
PubMed
Summary

Neuroimaging reveals altered brain connectivity in pediatric obsessive compulsive disorder (OCD), suggesting developmental factors influence its course. Future research should track these changes over time.

Keywords:
DTIPediatric OCDexecutive functionfMRIresting-statetask-control network

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Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Child Psychiatry

Background:

  • Pediatric obsessive compulsive disorder (OCD) is a complex disorder with significant neurobiological underpinnings.
  • Understanding the developmental trajectory of OCD is crucial for effective early intervention.

Purpose of the Study:

  • To review current neuroimaging research in pediatric OCD.
  • To explore the role of developmental mechanisms in OCD across the lifespan.

Main Methods:

  • Review of diffusion tensor imaging (DTI) studies.
  • Analysis of resting-state functional magnetic resonance imaging (fMRI) findings.
  • Examination of task-based fMRI research in pediatric OCD.

Main Results:

  • DTI studies indicate abnormal structural connectivity in the frontal-striato-thalamic circuity (FSTC) in pediatric OCD.
  • Resting-state fMRI reveals atypical FSTC connectivity and altered cortical network connectivity for task control.
  • Task-based fMRI suggests age and task difficulty influence brain activation patterns in pediatric OCD.

Conclusions:

  • Atypical neurodevelopmental trajectories likely contribute to the onset and progression of pediatric OCD.
  • Structural and functional connectivity abnormalities may be age-dependent.
  • Future research should integrate multiple neuroimaging techniques and longitudinal designs to identify developmental targets for intervention.