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Updated: Dec 1, 2025

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
Access to 2-pyridinylamide and imidazopyridine from 2-fluoropyridine and amidine hydrochloride
Yibiao Li1, Shuo Huang1, Jiaming Li1
1School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, 529020 China. Leeyib268@126.com kzhang@gdut.edu.cn.
Abstract:
Under catalyst-free conditions, an efficient method to synthesize 2-pyridinylamides has been developed, and the protocol uses inexpensive and readily available 2-fluoropyridine and amidine derivatives as the starting materials. Simultaneously, the copper-catalysed approach to imidazopyridine derivatives has been established with high chemoselectivity and regiospecificity. The results suggest that the nitrogen-heterocycles containing iodide substituents can also be compatible for the reaction via the cascade Ullmann-type coupling, and the nucleophilic substitution reaction provides the target products in a one-pot manner.
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