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Updated: Dec 1, 2025
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An Air-liquid Interface Bronchial Epithelial Model for Realistic, Repeated Inhalation Exposure to Airborne Particles for Toxicity Testing
Published on: May 13, 2020
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A consensus approach for estimating health risk: Application to inhalation cancer risks
Pascal Petit1, Anne Maître2, Dominique J Bicout3
1Grenoble Alpes University, CNRS, Grenoble INP, TIMC-IMAG (UMR 5525 CNRS - UGA), EPSP Team (Environment and Health Prediction of Populations), F-38000, Grenoble, France.
Environmental Research
|November 9, 2020
Summary
This study introduces a consensus risk indicator (CRI) to overcome challenges in risk assessment. The CRI offers a reliable, consistent method for comparing risks, aiding regulatory decisions and public health protection.
Area of Science:
- Environmental Health
- Toxicology
- Risk Assessment
Background:
- Risk assessments face challenges due to diverse and conflicting risk indicators.
- Existing methods can lead to discrepancies and inconsistent conclusions.
Purpose of the Study:
- To propose a structured approach for constructing a consensus risk indicator (CRI) distribution.
- To demonstrate the feasibility and ease of implementing the CRI for risk assessments.
- To enhance the reliability and comparability of risk assessment outcomes.
Main Methods:
- A CRI distribution is constructed using a weighted combination of existing indicators.
- Weights are determined by the overlapping areas between individual indicator distributions and a reference distribution.
- The approach is exemplified by assessing human cancer risk from inhalation exposure using eight indicators.
Main Results:
- The CRI distribution parameters for 199 carcinogenic chemicals via inhalation exposure were determined.
- An interactive table presents these CRI distribution parameters.
- A user-friendly web application, InCaRisk, was developed for cancer risk estimation.
Conclusions:
- The proposed CRI approach provides a reliable and consistent alternative for risk assessment.
- This method supports direct comparisons and can enhance regulatory decision-making.
- The approach is adaptable for various health outcomes, exposure routes, and settings, aiding public health protection.
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