Magnetic solid-phase extraction of gingerols in ginger containing products

Area of Science:

• Analytical Chemistry
• Materials Science
• Food Science

Background:

• Gingerols are bioactive compounds found in ginger with various health benefits.
• Accurate quantification of gingerols is crucial for quality control in food and supplement industries.
• Existing methods for gingerol extraction can be time-consuming and environmentally taxing.

Purpose of the Study:

• To synthesize a graphene oxide/magnetite (GO-Fe3O4) nanocomposite for magnetic solid-phase extraction (MSPE).
• To develop and optimize an MSPE method for the efficient extraction of gingerols from diverse matrices.
• To determine gingerols in commercial products using the developed MSPE coupled with HPLC-MS/MS.

Main Methods:

• Synthesis of graphene oxide/magnetite (GO-Fe3O4) nanocomposite.
• Development and optimization of magnetic solid-phase extraction (MSPE) parameters.
• Analysis of gingerols (6-gingerol, 8-gingerol, 10-gingerol) using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS).

Main Results:

• The GO-Fe3O4 nanocomposite effectively served as a sorbent for MSPE.
• The optimized MSPE method demonstrated high selectivity and analytical confidence.
• Achieved limits of detection (LOD) between 2-3 μg L-1 with good linearity (5-200 μg L-1) and accuracy.
• Intra-day and inter-day relative standard deviations (RSDs) were consistently low (1.7-13.4% and 0.4-10.9%).

Conclusions:

• The GO-Fe3O4-based MSPE coupled with LC-MS/MS is a practical, fast, efficient, and environmentally friendly technique.
• This hyphenated method provides a valuable tool for the confident quality control of gingerols in commercial products.
• The developed approach facilitates high-throughput analysis and reliable assessment of ginger-containing goods.