[Research progress of Pictet-Spenglerases]

Area of Science:

• Biochemistry
• Organic Chemistry
• Enzymology

Background:

• Pictet-Spenglerases (P-Sases) catalyze Pictet-Spengler (P-S) reactions.
• P-S reactions form tetrahydroisoquinoline and β-carboline alkaloids.
• These alkaloids are backbones for bioactive compounds and clinical drugs.

Purpose of the Study:

• To review research progress on P-Sases.
• To summarize their discovery, functional identification, and biological characteristics.
• To highlight their catalytic applications in chemoenzymatic synthesis.

Main Methods:

• Literature review of P-Sase research.
• Analysis of P-Sase discovery and functional studies.
• Compilation of P-Sase catalytic applications.

Main Results:

• P-Sases exhibit high stereoselectivity and regioselectivity.
• They operate under mild reaction conditions.
• Enzymatic products are crucial for synthesizing various drugs.

Conclusions:

• P-Sases are valuable biocatalysts for synthesizing complex alkaloids.
• Their unique catalytic properties are important for chemoenzymatic synthesis.
• This review provides a reference for future P-Sase research and development.