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DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Updated: Dec 1, 2025

Author Spotlight: Engineering Molecular Tools for Disease Detection and Imaging

Author Spotlight: Engineering Molecular Tools for Disease Detection and Imaging

Published on: December 8, 2023

Aptamer-Functionalized Microdevices for Bioanalysis.

Jing Xue¹, Feng Chen¹, Min Bai¹

¹Institute of Analytical Chemistry and Instrument for Life Science, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xianning West Road, Xi'an, Shaanxi 710049, P. R. China.

ACS Applied Materials & Interfaces

|November 10, 2020

Summary

This summary is machine-generated.

Aptamers offer advantages over antibodies for biological research and disease diagnosis. Aptamer-functionalized microdevices provide advanced bioanalysis platforms with potential for future applications.

Keywords:

aptamer bioanalysis microarray microfluidics nanomaterial paper strip

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Area of Science:

Biotechnology
Analytical Chemistry
Nanotechnology

Background:

Aptamers are advantageous recognition elements in biological research and disease diagnosis due to their stability, engineerability, and low immunogenicity, complementing antibodies.
Aptamer-functionalized microdevices offer compact, high-throughput, and precise bioanalysis platforms with minimal reaction volumes.

Purpose of the Study:

To review innovative aptamer selection technologies using microdevices.
To highlight advanced applications of aptamer-functionalized microdevices in bioanalysis for diverse targets.
To discuss challenges and future perspectives of these microdevices in bioanalysis.

Main Methods:

Review of aptamer selection techniques integrated with microdevices.
Analysis of diverse bioanalytical applications utilizing aptamer-functionalized microdevices.
Discussion of challenges and future trends in aptamer-based microdevice technology.

Main Results:

Aptamer-functionalized microfluidic devices, microarrays, and paper-based devices show significant potential for future bioanalysis.
Innovative technologies for aptamer selection with microdevices have been introduced.
Advanced applications of these platforms for detecting various targets have been highlighted.

Conclusions:

Aptamer-functionalized microdevices represent a promising frontier in bioanalysis.
Continued development in aptamer selection and microdevice integration will drive future advancements.
Addressing current challenges will unlock the full potential of these platforms.