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Updated: Dec 1, 2025
Fluorescence Recovery after Photobleaching of Yellow Fluorescent Protein Tagged p62 in Aggresome-like Induced Structures
Published on: March 26, 2019
A conformational tweak for enhanced cellular internalization, photobleaching resistance and prolonged imaging
Niranjan Meher1, Anil Parsram Bidkar2, Debasish Barman1
1Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, Assam, India. pki@iitg.ac.in.
Abstract:
A strategy of conformational tweaking regulates the condensed state behavior of naphthalimide skeletal isomers (NSIs) and enhances their photophysical properties, cellular uptake and prolonged imaging capability. This salient approach results in a large Stokes shift (>120 nm), rapid cellular internalization, photobleaching resistance, and efficient bioimaging of the ribbon-like nano-assembly superior to that of its electronically similar micro-flower isomer.
