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Identification of biomarkers and pathways in hypertensive nephropathy based on the ceRNA regulatory network

Zhen Wang1, Zhongjie Liu1, Yingxia Yang1

  • 1Nephrology Department, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, No.5 Haiyuncang Road, Dongcheng District, Beijing, 100700, China.

BMC Nephrology
|November 12, 2020
PubMed

Insights

This study identifies key RNA biomarkers, including specific microRNAs and long non-coding RNAs, involved in the insulin signaling pathway, offering new insights into hypertensive nephropathy mechanisms.

Area of Science:

  • Genomics and Molecular Biology
  • Renal Physiology
  • Biomarker Discovery

Background:

  • Hypertensive nephropathy (HTN) is a significant cause of renal injury due to chronic hypertension.
  • Understanding the molecular mechanisms and identifying biomarkers for HTN is crucial for patient outcomes.

Purpose of the Study:

  • To identify potential biomarkers for hypertensive nephropathy (HTN).
  • To elucidate the underlying molecular mechanisms of HTN development.

Main Methods:

  • Downloaded and analyzed gene expression data (GSE28260) from hypertensive and normotensive individuals.
  • Identified differentially expressed RNAs (DERs) and constructed a competing endogenous RNA (ceRNA) network.
  • Performed functional enrichment analyses (DAVID, GSEA) and KEGG pathway analysis.

Main Results:

  • Identified 947 DERs, including 900 DE-mRNAs, 20 DE-lncRNAs, and 27 DE-miRNAs.
  • lncRNAs KCTD21-AS1, LINC00470, and SNHG14 were identified as hub nodes in the ceRNA network.
  • The insulin signaling pathway was found to be directly associated with HTN, regulated by specific mRNAs, miRNAs, and lncRNAs.

Conclusions:

  • The insulin signaling pathway is directly implicated in hypertensive nephropathy.
  • Specific microRNA (has-miR-107) and lncRNAs (SNHG14, TUG1, ZNF252P-AS1, MIR503HG) serve as potential biomarkers for HTN.
  • Findings enhance understanding of HTN pathogenesis and progression.
Abstract

Keywords:
Differentially expressed RNAsFunctional analysisHypertensive nephropathyceRNA network directly associated with HTN

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