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Related Experiment Video

Updated: Nov 30, 2025

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Published on: October 20, 2021

A Trimodal Wireless Implantable Neural Interface System-on-Chip.

Yaoyao Jia, Ulkuhan Guler, Yen-Pang Lai

IEEE Transactions on Biomedical Circuits and Systems

|November 12, 2020

Summary

This summary is machine-generated.

This study presents a wireless, battery-less neural interface chip for recording and stimulating brain activity. The compact trimodal system-on-chip enables advanced neuroscience research and potential therapeutic applications.

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Last Updated: Nov 30, 2025

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Published on: October 20, 2021

Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa

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Published on: September 27, 2018

A Wireless, Bidirectional Interface for In Vivo Recording and Stimulation of Neural Activity in Freely Behaving Rats

A Wireless, Bidirectional Interface for In Vivo Recording and Stimulation of Neural Activity in Freely Behaving Rats

Published on: November 7, 2017

Area of Science:

Neuroscience
Biomedical Engineering
Electrical Engineering

Background:

Developing wireless, implantable neural interfaces is crucial for understanding brain function and treating neurological disorders.
Existing systems often face limitations in power, size, and multimodal capabilities.

Purpose of the Study:

To develop and validate a compact, wireless, and battery-less trimodal neural interface system-on-chip (SoC).
To integrate neural recording, electrical stimulation, and optical stimulation functionalities onto a single chip.

Main Methods:

Fabrication of a 5x3 mm² SoC using 0.35-μm CMOS technology.
Inductive powering and communication with OOK-PPM downlink telemetry (50 kbps) and OOK uplink telemetry (6.78 Mbps).
Analog front-end (AFE) with adjustable gain and low noise, SAR-ADC digitization, and RF transmission.
Switched-capacitor based stimulation (SCS) for optical stimulation and independently driven sites for electrical stimulation.
In vivo testing in anesthetized rats.

Main Results:

The trimodal SoC successfully integrated 16-ch neural recording, 8-ch electrical stimulation, and 16-ch optical stimulation.
Achieved wireless, battery-less operation with efficient data telemetry.
Demonstrated functional performance in in vivo animal studies.

Conclusions:

The developed trimodal neural interface SoC offers a promising platform for advanced neuroscience research.
Its compact size, wireless operation, and multimodal capabilities pave the way for novel brain-computer interfaces and neuromodulation therapies.