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Elevated 123I-MIBG Activity in Intramuscular Hemangioma
Wei Wang1, Xu Yang, Jigang Yang
1From the Department of Nuclear Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Clinical Nuclear Medicine
|November 12, 2020
Summary
A 3-year-old boy with high-risk neuroblastoma showed liver metastasis on an iodine-123 metaiodobenzylguanidine (123I-MIBG) scan. The scan also revealed uptake in an intramuscular hemangioma, which persisted on follow-up.
Area of Science:
- Nuclear medicine
- Pediatric oncology
- Radiopharmaceuticals
Background:
- Neuroblastoma is a high-risk pediatric cancer.
- 123I-MIBG scintigraphy is a key imaging modality for neuroblastoma.
- Post-treatment surveillance is crucial for managing high-risk neuroblastoma.
Observation:
- A 3-year-old boy with high-risk neuroblastoma underwent 123I-MIBG SPECT/CT after surgery and chemotherapy.
- The scan identified liver metastasis and mild uptake in the left erector spinae muscle.
- Contrast-enhanced CT indicated the erector spinae finding was an intramuscular hemangioma.
Findings:
- 123I-MIBG demonstrated metastatic disease in the liver.
- Persistent 123I-MIBG accumulation was observed in the intramuscular hemangioma.
- Follow-up imaging showed resolution of liver metastasis.
Implications:
- This case highlights the potential for 123I-MIBG uptake in benign lesions like intramuscular hemangioma.
- Accurate interpretation of 123I-MIBG scans is essential to differentiate malignancy from benign findings.
- Understanding incidental findings on 123I-MIBG scans aids in precise disease assessment in pediatric neuroblastoma patients.
