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α-Glucosidase inhibitory phenolics from Echeveria subrigida (B. L. Rob & Seaton) leaves
G López-Angulo1, V Miranda-Soto2, J A López-Valenzuela1
1School of Chemical and Biological Sciences, Autonomous University of Sinaloa, Culiacan, Sinaloa, Mexico.
Abstract:
Echeveria subrigida is native to Mexico and its methanol extract (ME) shows relevant biological activities for human health, including the α-glucosidase inhibitory (αGI) activity that suggests its antidiabetic potential. Fractionation of the ME based on the αGI activity (IC50 in µg/mL) showed that quercetin-3-O-β-glucoside (131.1), isorhamnetin-3-O-β-glucoside (166.4), and dimers to heptamers proanthocyanidins (9.6) were among the main responsible of αGI activity in the ME. The purified compounds showed better activity than acarbose (IC50 = 4426 µg/mL).
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