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Updated: Nov 30, 2025

A Strategy to Identify Compounds that Affect Cell Growth and Survival in Cultured Mammalian Cells at Low-to-Moderate Throughput
Published on: September 22, 2019
Development of potent inhibitors for strigolactone receptor DWARF 14
Masahiko Yoshimura1, Sojung F Kim2, Ryosuke Takise1
1Graduate School of Science Nagoya University, Chikusa, Nagoya, 464-8602, Japan.
Abstract:
Strigolactones (SLs) are plant hormones that suppress shoot branching through perception by their receptor protein DWARF 14 (D14). The artificial regulation of SL signaling has been considered a potent agricultural technique because plant architecture is strongly related to crop yield. In this communication, we describe the development of a small-molecule D14 inhibitor that functions at sub-micromolar levels. This potent inhibitor may be a lead compound for a first-in-class plant growth regulator.
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